Authors
Julia Veloso de Oliveira, Nora M Weiss, Barbara Wollenberg, Wilhelm Wimmer
Published in
Zeitschrift fur medizinische Physik. Oct 20, 2026. Epub Oct 20, 2026.
Abstract
electrically evoked compound action potentials (ECAPs) are among the few objective measures of auditory nerve activity available in clinical practice and provide valuable insight into a patient's neural status. ECAP recordings are typically performed using different electrodes for stimulation and recording to avoid amplifier saturation caused by electrode polarization. However, same-electrode recording could reduce the spatial separation between the site of neural activation and the recording site, potentially providing a more localized assessment of neural activity and improving the sensitivity of ECAP-based biomarkers. Here, we introduce a method to characterize stimulation artifacts and estimate their parameters using a previously published impedance model. The artifact waveform was described by a shared double exponential function, while electrical components of an equivalent circuit were estimated from impedance measurements acquired with multiple pulse durations. Artifact recordings exhibited clear polarity-dependent behavior. Nevertheless, the amplitude of the fast exponential component showed a significant association with its impedance-based estimate (fixed-effect coefficient β=0.37 and β=0.44 for anodic-cathodic and cathodic-anodic stimulation, respectively; p<0.001). Furthermore, longitudinal changes in the fast exponential component were similar to changes in near-field impedance subcomponent, suggesting that the ECAP artifact could be partially influenced by postoperative changes at the electrode-electrolyte interface.
PMID:
42901842
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.
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