Interpreting metabolite associations and proposed biosynthetic routes in Lactiplantibacillus plantarum-fermented Porphyra haitanensis.

Authors

Nuo Chen, Xin Zhang

Published in

Food microbiology. Volume 142. Pages 105312. Epub Sep 23, 2026.

Abstract

The recent study by Li et al. links Lactiplantibacillus plantarum fermentation of Porphyra haitanensis with enhanced in vitro lipid-lowering-related activities, metabolomic remodeling, and beverage development. We welcome this integrative approach but suggest that the mechanistic interpretation of γ-aminobutyric acid (GABA) and p-coumaric acid (pCA) should be calibrated to the evidence. Untargeted LC-MS supports fermentation-associated changes in relative abundance, yet metabolite identity and concentration require orthogonal confirmation and targeted quantification. Likewise, accumulation of pCA cannot distinguish de novo synthesis from release of pre-existing phenolics or altered turnover, and neither GABA nor pCA was directly shown to mediate the observed enzyme- or micelle-related effects. The marked rise in pancreatic lipase inhibition after formulation and pasteurization further warrants vehicle and pH-matched controls to exclude matrix effects. We propose targeted validation of metabolite identity, flux, enzyme activity, and compound-specific function to strengthen the proposed biosynthetic and functional links.

PMID:
42901665
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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