The Effect of Stevioside on Hepatic Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Authors

Changfa Zhang, Wenli Li, Kangjun Li, Ruoting Wang, Lili Kang, Miaoguan Peng, Guowei Li

Published in

Journal of agricultural and food chemistry. Volume 74. Issue 41. Pages 32309-32317. Oct 21, 2026.

Abstract

Stevioside is a widely used natural non-nutritive sweetener derived from Stevia rebaudiana; however, its effects on MASLD and the underlying molecular mechanisms remain unclear. This study aimed to elucidate the effects and mechanisms of stevioside on MASLD, based on the high-fat diet-induced mice model and palmitic acid-treated hepatocyte model. We found that stevioside significantly alleviated hepatic steatosis in MASLD mice and reduced plasma ALT and AST levels and hepatic triglyceride and total cholesterol. In palmitic acid-induced hepatocytes, stevioside significantly reduced intracellular lipid droplet content and upregulated the protein levels of p-AMPK, PPARα, and EHHADH. Pharmacological inhibition of AMPK and PPARα revealed that stevioside regulated PPARα expression and downstream EHHADH expression in an AMPK-dependent manner. To conclude, stevioside significantly improved hepatic steatosis in MASLD by activating the AMPK/PPARα/EHHADH pathway, potentially generating novel evidence to help control the escalating disease burden of MASLD from the perspective of natural sweetener.

PMID:
42905007
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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