Lactobacillus gasseri LG-G12 Alleviates High-Fat Diet-induced Obesity through Gut Microbiota-Bile Acid Axis.

Authors

Yating Luo, Simou Wu, Jinxing Li, Lei Ren, Wen Jia, Mingxin Yang, Dongyue Ouyang, Yun Li, Fang He, Ruyue Cheng

Published in

Journal of agricultural and food chemistry. Volume 74. Issue 41. Pages 32256-32271. Oct 21, 2026.

Abstract

The role of probiotics in weight management remains controversial. In this study, we found that Lactobacillus gasseri LG-G12 exhibits gut colonization capacity and metabolic regulation potential in vitro. In vivo, LG-G12 alleviated high-fat diet-induced weight gain and visceral fat accumulation in mice. Fecal targeted metabolomics identified bile acid metabolism as a key pathway. Furthermore, LG-G12 might exhibit bile salt hydrolase and hydroxysteroid dehydrogenase activities, contributing to a bile acid profile characterized by low cholic acid and high ursodeoxycholic acid levels. Additionally, LG-G12 increased the abundance of deoxycholic acid-producing Eubacterium spp., leading to elevated DCA levels. This distinct bile acid profile activated FXR and TGR5, reducing lipid accumulation and adipocyte differentiation in the liver and epididymal adipose tissue, and promoting thermogenesis in brown adipose tissue. Collectively, these findings demonstrate that LG-G12 ameliorates high-fat diet-induced obesity via the gut microbiota-bile acid axis, positioning LG-G12 as a promising candidate for weight management.

PMID:
42904999
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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