Authors
Yue Zhang, Yue Fang, Yan Chen, Quan Chen, Wenwen Liu, Min Xu, Lihua Xing, Rulin Wang, Lei Wang, Nianjun Yu, Daiyin Peng, Yanyan Wang, Weidong Chen
Published in
International journal of biological macromolecules. Volume 331. Issue Pt 2. Pages 148476. Epub Oct 25, 2025.
Abstract
Clinical and experimental evidence suggests a link between gut microbiota dysbiosis and ulcerative colitis (UC). Although our prior work indicated that Poria cocos polysaccharides (PCP) enhance intestinal health by modulating the gut microbiota, the mechanisms underlying their protection against UC were not fully delineated. In this study, in vivo and in vitro experiments demonstrated that PCP supplementation ameliorates dextran sulfate sodium (DSS)-induced gut microbiota dysbiosis, increasing the abundance of Parabacteroides distasonis (P. distasonis). The protective role of P. distasonis was confirmed by its supplementation in microbiota-depleted mice, which restored gut barrier integrity and mitigated histopathological damage. Metabolomics analysis revealed that PCP significantly increases the levels of secondary bile acids. Further research has found that PCP serves as a carbon source to promote the proliferation of P. distasonis, enhances bile salt hydrolase activity, stimulates the production of (Deoxycholic acid, DCA), (Lithocholic acid, LCA), and (Isolithocholic acid, isoLCA), and alleviates UC by activating the TGR5-cAMP-PKA-NLRP3 signaling pathway. Treatment with TGR5 agonists and inhibitors in UC mice demonstrated the involvement of PCP in this pathway. Collectively, these findings indicate that PCP can be utilized as a novel prebiotic for the treatment of UC.
PMID:
42904778
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.
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