The Paradoxical Effect of Levetiracetam: A Case of Nonconvulsive Status Epilepticus Following Stereoelectroencephalography Implantation.

Authors

Huan Lian, Wei Dan, Li Jiang, Xinyi Liang

Published in

Clinical EEG and neuroscience. Pages 15500594261499558. Oct 21, 2026. Epub Oct 21, 2026.

Abstract

The paradoxical effect of levetiracetam (LEV) refers to the paradoxical aggravation of epileptic seizures during clinical application. In this case, we report for the first time a patient with MRI-negative drug-resistant frontal lobe epilepsy who developed nonconvulsive status epilepticus (NCSE) following LEV dose escalation, as documented by stereoelectroencephalography (SEEG). The SEEG findings suggested that paradoxical activation of mesial temporal structures may be involved in the occurrence of LEV-induced paradoxical effects.

PMID:
42904691
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.