From cytoreduction to precision oncology: evolution of ovarian cancer therapy.

Authors

Ghassan M Saed, Laura Detti, Dina Massad, Asma Basha, Robert T Morris

Published in

Journal of ovarian research. Volume 19. Issue 1. Jul 25, 2026. Epub Jul 25, 2026.

Abstract

Ovarian cancer remains the most lethal gynecologic malignancy due to its asymptomatic progression, limited screening modalities, and late-stage diagnosis. Although initial responses to platinum-based chemotherapy are common, recurrence and multidrug resistance are nearly universal, necessitating a shift toward biomarker-guided, precision-based interventions. This review synthesizes current evidence on the evolving landscape of ovarian cancer treatment, with emphasis on molecular pathogenesis, histotype-specific vulnerabilities, and advances in therapeutic strategies. Focus is placed on the clinical integration of poly (ADP-ribose) polymerase (PARP) inhibitors, vascular endothelial growth factor (VEGF)-targeting agents, immune checkpoint inhibitors, and antibody-drug conjugates, alongside emerging platforms such as liquid biopsy, artificial intelligence-enhanced diagnostics, and histotype-driven targeted therapies. Translational insights from other malignancies were utilized to highlight future directions for ovarian cancer, including dual pathway targeting, immune and epigenetic modulation, and receptor-guided cytotoxic delivery. Collectively, these advances demonstrate how precision oncology is advancing ovarian cancer treatment, with the potential to improve survival outcomes while preserving quality of life.

PMID:
42907928
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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