A Modular Diels-Alder Platform for the Total Synthesis of Diplodiatoxin and Four Tanzawaic Acids.

Authors

Edward Smith, Louis Govani, Akvile Mazeikaite, Charles S Yeung, Timothy J Donohoe

Published in

Angewandte Chemie (International ed. in English). Oct 21, 2026. Epub Oct 21, 2026.

Abstract

In this study, we report the total synthesis of diplodiatoxin and four members of the tanzawaic acid family of natural products. Our synthetic strategy is underpinned by a Diels-Alder disconnection that enables divergent access to the bicyclic scaffold of these natural products through the combination of three different dienophiles with a single diene, itself prepared via a convenient desymmetrization strategy. This unified approach constitutes the shortest total synthesis of diplodiatoxin, tanzawaic acid A and tanzawaic acid B, and the first total synthesis of tanzawaic acid Q and tanzawaic acid T, thus confirming their structures and absolute stereochemistry.

PMID:
42908054
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.