Effects of local vibration therapy and gabapentin on restless legs syndrome symptoms: a randomized controlled trial.

Authors

Gholamreza Raissi, Bijan Forogh, Hamid Ansari, Seyed Pezhman Madani, Masumeh Bagherzadeh Cham, Hosna Soleymanzadeh

Published in

BMC research notes. Volume 19. Issue 1. Jul 27, 2026. Epub Jul 27, 2026.

Abstract

This study aimed to evaluate the effect of LV in combination with gabapentin, a first-line medication for RLS, on the treatment of patients with the condition.
In total, 36 participants (18 in each group) participated in this study, with 10 (55%) being male within each group. The mean age of participants was 45 years (SD = 10.6) in the LV group and 49.1 (SD = 8.3) in the gabapentin group. In both the LV and gabapentin groups, IRLSSG scores decreased significantly after the intervention compared with baseline (p < 0.001). However, scores increased at the one-month follow-up, although they remained lower than pre-intervention values (p < 0.001). A similar pattern was observed for the PSQI scores (p < 0.001). There were no significant differences between groups at any timepoint (p > 0.05).
The study protocol was registered at the Iranian Registry of Clinical Trials on August 30th, 2023 (code IRCT20190306042945N4).

PMID:
42908006
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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