[A Questionnaire-based Survey Regarding Implementation and Operation of Radionuclide Therapy in the Chugoku-Shikoku Region of Japan].

Authors

Naoya Hayashi, Komei Takauchi, Yusuke Uehara, Ryotaro Tokorodani, Nobuhiro Yada

Published in

Nihon Hoshasen Gijutsu Gakkai zasshi. Volume 82. Issue 12.

Abstract

To clarify the clinical operation of radionuclide therapy, we conducted a questionnaire survey of institutions performing radionuclide therapy in the Chugoku-Shikoku region of Japan, focusing on admission and discharge management, post-therapy imaging purposes, and SPECT acquisition and processing conditions for ¹³¹I-Na and ¹⁷⁷Lu-DOTA-TATE therapy.
A web-based questionnaire was sent to 17 institutions performing radionuclide therapy in the region. The survey included clinical operations, post-therapy imaging practices, imaging purposes, and SPECT acquisition and processing parameters. Exploratory stratified analyses were performed according to facility type, annual treatment volume, and collimator type.
Responses were obtained from 15 institutions. ¹³¹I-Na therapy was performed at all institutions; however, length of hospital stay, imaging timing, and SPECT acquisition conditions varied among institutions. For 3.7 GBq ¹³¹I-Na therapy, length of stay ranged from 1 to 7 nights, and no clear relationship with facility type or treatment volume was observed. Post-therapy imaging after ¹³¹I-Na administration was performed to confirm radiopharmaceutical distribution in all institutions, and none used it for quantitative assessment or dosimetry. ¹⁷⁷Lu-DOTA-TATE therapy was implemented in 67% of institutions, and admission schedules showed a certain degree of standardization. Post-therapy imaging was performed at almost all institutions; the main purpose was confirmation of radiopharmaceutical distribution, whereas some institutions used imaging for SUV assessment or dosimetry. Differences remained in collimator type, energy window settings, and acquisition protocols.
Admission and discharge management for ¹⁷⁷Lu-DOTA-TATE therapy was relatively standardized, whereas inter-institutional differences remained in post-therapy imaging purposes and protocols. In ¹³¹I-Na therapy, substantial differences were observed in admission and discharge management and post-therapy imaging conditions. These findings may provide basic information for standardizing clinical operations in radionuclide therapy.

PMID:
42907400
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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