Cutaneous malignant melanoma with ovarian and intracranial metastases: a case report.

Authors

Fei Yu, Jun Yang, Lifang Lan, Wenjuan Yi

Published in

American journal of cancer research. Volume 16. Issue 9. Pages 3916-3920. Epub Sep 15, 2026.

Abstract

Cutaneous malignant melanoma is an aggressive malignancy with a high metastatic potential, and although ovarian metastasis is extremely rare, it may be easily overlooked or misdiagnosed due to its nonspecific clinical manifestations. Here, we report a rare case of bilateral ovarian metastases from cutaneous malignant melanoma in a 51-year-old female patient who presented with abdominal pain one year after surgical resection of the primary skin lesion. Pelvic imaging revealed bilateral ovarian masses measuring 12 × 10 cm on the left side and 10 × 9 cm on the right side. The patient subsequently underwent total hysterectomy, bilateral adnexectomy, and resection of the greater omentum. Histopathological examination combined with immunohistochemical staining confirmed metastatic malignant melanoma of the ovaries, with tumor cells showing positive expression of SOX10, HMB45, and Melan-A. Molecular analysis revealed a BRAF mutation, and subsequent magnetic resonance imaging demonstrated multiple brain metastases. The patient was treated with whole-brain radiotherapy combined with vemurafenib-targeted therapy.

PMID:
42908857
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.