Exploring the antioxidant and hepatoprotective activity of Euphorbia hirta L. against arecoline-induced liver damage: an in vivo and in silico study.

Authors

Priyakrishna Yumnam, Linda B Hrangkhol, Meenakshi Bawari

Published in

In silico pharmacology. Volume 14. Issue 3. Pages 263. Epub Oct 20, 2026.

Abstract

Euphorbia hirta L. has been traditionally used for the treatment of respiratory disorders, liver ailments, and metabolic disorders. The GC-MS analysis of the methanolic extract of E. hirta identified 33 bioactive compounds. Arecoline administration in mice elevated oxidative and nitrosative stress and liver biomarker enzymes. Treatment with the methanolic extract of E. hirta at doses of 500 mg/kg and 250 mg/kg restored elevated oxidative and nitrosative stress and liver biomarker enzymes in a dose-dependent manner. In silico, PASS analysis predicted the potential bioactivity of phytoconstituents. Molecular docking revealed that various phytocompounds exhibited strong binding affinity with potential antioxidant and hepatoprotective receptors and showed desirable ADME/Tox profiles. The in vivo and in silico studies support the potential of the methanolic extract of E. hirta for hepatoprotection.
The online version contains supplementary material available at https://doi.org/10.1007/s40203-026-00770-w.

PMID:
42908706
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.