Authors
Yuxin Zheng, Desheng Liu, Jun Hou, Hong Ding, Yingying He
Published in
Frontiers in genetics. Volume 17. Pages 1975296. Epub Sep 28, 2026.
Abstract
Chromatin remodeling contributes to skeletal development, tissue homeostasis, and disease by regulating nucleosome positioning, chromatin accessibility, and histone modifications. Bone organoids can partially reproduce the three-dimensional human bone microenvironment and provide new in vitro models for studying skeletal pathophysiology. This review summarizes recent progress in chromatin remodeling and bone organoid research, with a focus on the roles of switch/sucrose non-fermenting (SWI/SNF), imitation switch (ISWI), and chromodomain helicase deoxyribonucleic acid (DNA)-binding (CHD) complexes in bone organoid regulation. We also discuss the relationships between bone organoids and enhancer remodeling, DNA methylation, histone modifications, chromatin organization, and cellular metabolism. In addition, we summarize the applications of emerging technologies, including multiomics, spatial epigenomics, and live cell imaging, in bone organoid studies. The current limitations of these models are also considered. Finally, we discuss potential directions for the further development and refinement of bone organoids. We highlight their potential applications in bone disease research, drug screening, and future clinical translation within the context of chromatin remodeling.
PMID:
42909312
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.
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