Cutaneous endothelial cells and their roles in wound healing.

Authors

Haiming Li, Laura Sormani Le Bourhis, Seen-Ling Sim, Abbas Shafiee, Kiarash Khosrotehrani

Published in

JID innovations : skin science from molecules to population health. Volume 6. Issue 6. Pages 100539. Epub Sep 10, 2026.

Abstract

Endothelial cells (ECs) form the inner monolayer of blood and lymphatic vessels play an essential role in skin homeostasis and wound healing. Upon injury, ECs rapidly engage in the healing response. ECs promote wound healing by forming new blood vessels through angiogenesis to supply oxygen, nutrients, and signals needed for tissue repair. Diseases like diabetes can cause endothelial dysfunction, leading to defective neovascularization and delayed wound closure. This review focuses on the intrinsic roles of ECs in each phase of skin wound healing, extending beyond their roles in vascularization, and discusses therapeutic strategies that target those functions to improve healing outcomes. Recognizing ECs as dynamic regulators of wound repair, rather than merely structural components of blood vessels, could open new therapeutic avenues for regenerative skin therapies.

PMID:
42909176
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.