Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe chronic kidney disease in a dog.

Authors

Yu Yu, Xuemin Lv, Xinyuan Zhou, Yuxin Ma, Hao Li, Weiwei Wang, Yizhe Song

Published in

Frontiers in veterinary science. Volume 13. Pages 1977920. Epub Oct 07, 2026.

Abstract

This case report explored the clinical improvement and short-term tolerability of allogeneic adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment of severe chronic kidney disease (CKD) in dogs. A 9-year-old female Pomeranian was diagnosed with chronic kidney disease (CKD) caused by acute kidney injury and, after conventional treatment failed, received intravenous infusion of AD-MSCs from healthy donor dogs. The AD-MSCs were aseptically collected, isolated, cultured, characterized, and subjected to microbiological safety testing, and were then administered intravenously at a dose of 3 × 10⁶cells/kg every 2 weeks for a total of four infusions, with dexamethasone premedication to reduce the risk of adverse reactions. Following AD-MSC administration and continued conventional care, reductions in serum creatinine and phosphorus and a downward trend in blood urea nitrogen were observed, along with improvements in body weight, body condition score, appetite, and mental status; no adverse events were observed. The results of this case suggest the feasibility and short-term tolerability of allogeneic AD-MSCs for severe CKD in dogs and provide a reference for clinical research on cell-based therapy for canine CKD.

PMID:
42909056
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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