Interventricular septal fat-containing mass most consistent with cardiac lipoma in an adult with tuberous sclerosis complex.

Authors

Saubhagya Dhakal, Paulo Savoia, Nikahat Yasmine, Manisha Sharma

Published in

Radiology case reports. Volume 21. Issue 12. Pages 6519-6523. Epub Oct 13, 2026.

Abstract

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder in which cardiac rhabdomyomas and myocardial fatty foci are recognized cardiac manifestations, whereas discrete cardiac lipoma-like masses are uncommon. We report a 42-year-old woman with genetically and clinically confirmed TSC who underwent contrast-enhanced chest CT for surveillance of pulmonary lymphangioleiomyomatosis. CT demonstrated a well-circumscribed homogeneous macroscopic-fat attenuation mass centered in the mid-to-apical interventricular septum, measuring 2.8 × 2.2 × 2.0 cm with mean attenuation of approximately -92 HU and mild contour bulging toward the right ventricular cavity. The discrete mass-like morphology and homogeneous macroscopic fat favored cardiac lipoma over a typical TSC-associated myocardial fatty focus, although definitive distinction remains limited in the absence of dedicated cardiac MRI or histopathologic confirmation. This case emphasizes the imaging differential of fat-containing myocardial lesions in adults with TSC and the importance of integrating lesion morphology, size, tissue composition, and mass effect rather than relying on septal location alone.

PMID:
42909378
Bibliographic data and abstract were imported from PubMed on 23 Oct 2026.

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