Authors
Ron Pery, Matthias Ilmer, Rory L Smoot, Cornelius A Thiels, Susanne G Warner, Jennifer L Leiting, Patrick P Starlinger, Robert A Vierkant, Mark J Truty, Michael L Kendrick
Published in
HPB : the official journal of the International Hepato Pancreato Biliary Association. Sep 30, 2026. Epub Sep 30, 2026.
Abstract
Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with generally favorable outcomes following surgical resection. However, recurrence can occur in a small subset of patients, and clinicopathologic factors associated with recurrence remain incompletely defined. We evaluated the surgical management and long-term outcomes of patients undergoing resection for SPN at the Mayo Clinic.
A retrospective review of patients undergoing pancreatectomy for SPN between 2000 and 2024 was performed, analyzing demographic, clinical, operative, pathological and survival data.
Seventy-four patients underwent pancreatic resection for SPN. Median age was 28 years (IQR 22-44), and 67 patients (90.5%) were female. Margin-negative resection was achieved in 71 patients (95.9%). After a median follow-up of 5.8 years (IQR 1.9-9.0), five patients (6.8%) developed recurrence, and no disease-specific deaths occurred. Major vascular involvement, positive resection margins, and adjacent organ involvement were associated with reduced recurrence-free survival.
SPN is associated with excellent long-term outcomes following surgical resection, with durable disease control and no disease-specific mortality in this series. Recurrence was uncommon and occurred in patients demonstrating adverse clinicopathologic features. Larger multicenter studies are needed to better define recurrence risk and guide postoperative surveillance.
PMID:
42919784
Bibliographic data and abstract were imported from PubMed on 24 Oct 2026.
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