Effectiveness of artificial intelligence-assisted colonoscopy for colorectal lesion detection: a systematic review and meta-analysis of randomized controlled trials.

Authors

Xia Liu, Jian Qin, Yuxia Zhao, Chen Zhang, Dengchao Wang, Tao Jiang

Published in

BMC medical imaging. Volume 26. Issue 1. Jul 28, 2026. Epub Jul 28, 2026.

Abstract

Colonoscopy is the gold standard for colorectal cancer detection and prevention, but its performance depends on operator skill and lesion features. Artificial intelligence (AI)-assisted colonoscopy has been introduced to improve adenoma detection.
A comprehensive search was conducted in PubMed, Embase, the Cochrane Library, Web of Science, ClinicalTrials.gov, and major Chinese databases to identify randomized controlled trials (RCTs) comparing AI-assisted and conventional colonoscopy. Meta-analyses were performed using Review Manager 5.4 and Stata 14.0. The quality of evidence was graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, while trial sequential analysis (TSA) was applied to assess the robustness and information sufficiency of the results.
A total of 46 RCTs encompassing 37,012 participants were included. Compared with conventional colonoscopy, AI-assisted colonoscopy was associated with a higher ADR (RR = 1.22, 95% CI = 1.17-1.27, P < 0.00001), polyp detection rate (PDR: RR = 1.22, 95% CI = 1.16-1.29, P < 0.00001), polyp detection per colonoscopy (PPC: MD = 0.28, 95% CI = 0.21-0.36), and adenoma detection per colonoscopy (APC: MD = 0.22, 95% CI = 0.15-0.29). The detection rate of sessile serrated lesions (SSL) was also higher in the AI-assisted group (RR = 1.20, 95% CI: 1.05-1.36, P = 0.007), whereas no significant difference was observed in advanced adenoma detection rate (AADR).
AI-assisted colonoscopy was associated with improvements in several detection-related quality indicators, including ADR, PDR, PPC, APC, and SSL detection rate. However, given the very low GRADE certainty for ADR and PDR and the lack of long-term outcome data, these findings should be interpreted cautiously.
Not applicable.

PMID:
42919249
Bibliographic data and abstract were imported from PubMed on 24 Oct 2026.

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