Blue eyes in Felis catus: genetics and health impacts.

Authors

Olga Shatokhina, Eleanor Curtis, Victoria S Foster

Published in

Companion animal health and genetics. Volume 13. Issue 1. Oct 22, 2026. Epub Oct 22, 2026.

Abstract

Blue eyes and a colored coat are a sought-after trait in Felis catus. The dominant blue eye (DBE) phenotype arises from mutations within the PAX3 gene and is characterized by blue eyes on the background of a colored coat. Our review of the literature highlights the characteristics of four DBE variants, DBE^CEL, DBE^RE, DBE^ALT and DBE^AGO, emphasizing their diverse phenotypic expressions, including blue eye color and white spotting to associated risks of sensorineural hearing loss (SNHL) across cat breeds. We also highlight breed-specific disorders arising from limited gene pools, and given pathological effects of inbreeding and posit that responsible breeding strategies must prioritize genetic diversity to improve animal welfare. As DBE^RE variants resulted in high kitten mortality, with homozygous variants predicted to result in prenatal lethality and heterozygosity associated with a risk of SNHL and continuing to breed with this gene cannot be considered ethical under German Law. DBE^ALT, DBE^CEL and DBE^AGO heterozygote felines have not yet been shown to exhibit SNHL. We sought to categorize DBE variant effects on cats, understand if this is comparable to other species and explain further the mechanism between eye color and SNHL.

PMID:
42919426
Bibliographic data and abstract were imported from PubMed on 24 Oct 2026.

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