Clinical and radiological features of posterior reversible encephalopathy syndrome in children: a retrospective study.

Authors

Hua Huang, Shujuan Jiang, Huan Xu, Jingmin Zhang, Daogang Qin

Published in

Frontiers in pediatrics. Volume 14. Pages 1878823. Epub Oct 09, 2026.

Abstract

Posterior reversible encephalopathy syndrome (PRES) is an uncommon but critical neurological emergency in children. Data on Chinese pediatric cohorts remain limited.
To analyze the clinical features, imaging findings, and treatment of PRES in children to improve early diagnosis and management.
A retrospective analysis was conducted on 10 children diagnosed with PRES from March 2016 to January 2025.
The patients included 7 males and 3 females, aged 3-13 years (mean 7.5 years). The main underlying diseases were acute lymphoblastic leukemia (3 cases) and nephrotic syndrome (3 cases). Eight children (80%) had hypertension, 6 (60%) had hypoalbuminemia, and 8 received glucocorticoids or immunosuppressants. The main symptoms were headache, seizures, impaired consciousness, and visual disturbances. Cranial MRI showed symmetrical long T1 and long T2 signals in bilateral posterior cerebral white matter. After comprehensive treatment including antihypertensive, anticonvulsant, and dehydration therapy, all symptoms resolved and lesions disappeared on follow-up imaging without sequelae.
Pediatric PRES is an acute reversible disorder associated with hypertension and immunosuppressive therapy. Early MRI diagnosis and prompt intervention can significantly improve prognosis.

PMID:
42920612
Bibliographic data and abstract were imported from PubMed on 24 Oct 2026.

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