TorPause: Efficient Static Organ Preservation for Transplants.

Authors

Joydeep Bhadury, Tetsuya Tajima, Fabian P Suchy, Hideki Masaki, Moises Rivera, Jinyu Zhang, Toshiya Nishimura, Carsten T Charlesworth, Carlos O Esquivel, Hiromitsu Nakauchi

Published in

bioRxiv : the preprint server for biology. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Transplantation is limited by how long organs survive outside the body. Current methods slow metabolism or sustain physiological support, but neither eliminates ischemia-reperfusion injury, which shortens storage and drives organ discard. Embryonic diapause and hibernation show that mammalian cells retain a latent capacity for reversible metabolic arrest. Screening the PI3K-mTOR axis, we identified a dual inhibitor that reversibly pauses embryonic stem cells at ambient oxygen and holds mouse embryos in arrest for 8.5 days. Combined with a mitochondria-targeted hydrogen sulfide donor, this yields TorPause, a two-component flush compatible with existing preservation protocols. In a rat liver transplantation model, TorPause reduced structural injury and improved recipient survival after 5 hours of static storage at room temperature, potentially expanding the usable donor pool.

PMID:
42926724
Bibliographic data and abstract were imported from PubMed on 25 Oct 2026.

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