Lipoplex Nanoparticle-Based RNA Delivery to 3D Melanoma Spheroids.

Authors

Rüdiger Rudolf, Tiziana Cesetti, Florian Keller, Mathias Hafner

Published in

Methods in molecular biology (Clifton, N.J.). Volume 3089. Pages 541-549.

Abstract

Lipoplex nanoparticle-based vaccination technologies have shown tremendous efficiency for in vivo transfection during the COVID-19 pandemic and also hold promise for treating melanoma. While pharmacodynamics and pharmacokinetics need careful in vivo and clinical testing, other parameters of drug performance can be assessed with in vitro systems as well. Spheroids composed of more than one cell type can serve to assess drug penetration, cell-type specificity, and transfection efficiency at an early stage of drug development.

PMID:
42926296
Bibliographic data and abstract were imported from PubMed on 25 Oct 2026.

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