Authors
Dingkun Wang, Wenyao Cai, Ruonan Wang, Wenbo Luo, Yang Liu, Quan Zhou, Yu Jiang
Published in
Annals of clinical biochemistry. Pages 45632261502362. Oct 23, 2026. Epub Oct 23, 2026.
Abstract
Low-density lipoprotein cholesterol (LDL-C) and non-HDL cholesterol (non-HDL-C) reflect cholesterol mass, whereas apolipoprotein B (ApoB) reflects atherogenic particle number. We examined residual ApoB elevation after both cholesterol thresholds had been met and its distribution across triglyceride levels.
We analysed the 2005-2016 fasting subsample of the National Health and Nutrition Examination Survey (NHANES) among adults aged 30-79 years. The primary subgroup had LDL-C <2.59 mmol/L [100 mg/dL] and non-HDL-C <3.36 mmol/L [130 mg/dL]; residual elevation was defined as ApoB ≥0.90 g/L [90 mg/dL]. NHANES estimates and regressions accounted for the complex survey design. CHNS 2009 provided an unweighted consistency assessment.
Of 10,451 NHANES participants, 3,132 met both thresholds and 163 had ApoB ≥0.90 g/L. Weighted prevalence was 5.4% (95% CI 4.4-6.4), rising to 18.2% with triglycerides ≥1.69 mmol/L [150 mg/dL], compared with 2.9% below this threshold. The clinical model yielded an odds ratio of 6.23 (95% CI 3.68-10.53; P<0.001). Prevalence varied by ApoB threshold (22.9% at ≥0.80 g/L; 0.9% at ≥1.00 g/L). In CHNS, corresponding triglyceride-stratified prevalences were 8.9% and 1.9%.
Residual ApoB elevation after simultaneous LDL-C and non-HDL-C threshold attainment was concentrated in adults with higher triglycerides. Triglyceride levels offer a readily available means of identifying a subgroup with substantially greater yield from ApoB measurement.
PMID:
42925140
Bibliographic data and abstract were imported from PubMed on 25 Oct 2026.
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