Spatiotemporal Changes in the Cytokine Profile in the Brain of A53T Transgenic Mice, a Model of Parkinson's Disease.

Authors

Elizaveta L Alperina, Galina V Idova, Svetlana Ya Zhanaeva, Maria A Tikhonova, Margarita M Gevorgyan, Lyubomir I Aftanas

Published in

Biochemistry. Biokhimiia. Volume 91. Issue 10. Pages 1991-2000.

Abstract

Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD), a widespread chronic neurodegenerative disorder. However, the dynamics of cytokine alterations in the brain during disease progression remain poorly understood. In this study, we investigated the levels of pro-inflammatory (IL-6, IL-17A, and IFN-γ) and anti-inflammatory (IL-4 and IL-10) cytokines in selected brain regions of transgenic A53T mice that express a mutant form of human α-synuclein and develop age-dependent pathological and behavioral abnormalities (a widely used model of PD). In young A53T mice (2- and 5-month-old), reduced emotionality was accompanied by elevated levels of the pro-inflammatory cytokines IL-6 and IL-17A in the striatum compared with age-matched control mice. In contrast, 10-month-old A53T mice exhibiting motor impairments showed reduced levels of IL-6, IFN-γ, and IL-4 in the striatum, together with increased IL-10 levels in the frontal cortex. Thus, age-dependent behavioral abnormalities in A53T mice were associated with distinct changes in the content of pro- and anti-inflammatory cytokines. The levels of all cytokines examined were altered in the striatum, whereas only IL-10 was significantly changed in the frontal cortex. No differences between A53T and control mice were detected in cytokine levels in the hippocampus. The observed spatiotemporal patterns of immune and inflammatory alterations may contribute to a better understanding of neuroinflammatory mechanisms underlying PD progression and may provide a basis for identifying potential biomarkers and therapeutic targets.

PMID:
42927756
Bibliographic data and abstract were imported from PubMed on 26 Oct 2026.

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