Preoperative statin exposure and postoperative outcomes after primary shoulder arthroplasty: a propensity-matched analysis.

Authors

Kyle Stump, Lasya Sethi, Safari Baron, Nicholas Joseph Allen, Leslie Barnes

Published in

Clinics in shoulder and elbow. Oct 26, 2026. Epub Oct 26, 2026.

Abstract

Statin use is associated with reduced incidence of periprosthetic fracture and revision surgery following total hip and knee arthroplasty, but whether a similar relationship exists for shoulder arthroplasty remains unclear. The objective of this study was to evaluate the association between preoperative statin exposure and both short- and long-term complications following primary shoulder arthroplasty.
The TriNetX Research Network was used to identify patients who underwent primary total shoulder arthroplasty or shoulder hemiarthroplasty; they were separated into groups according to presence or absence of at least one statin prescription issued within the 3 months prior to surgery. Primary outcomes assessed included periprosthetic fracture and revision surgery using Kaplan-Meier survival analysis within 2 and 5 years.
A total of 21,346 matched pairs were included. Rates of periprosthetic fracture and revision surgery were similar within 2 years. The 5-year incidence of revision surgery was minimally elevated in the statin-exposed cohort (hazard ratio, 1.096; 95% CI, 1.002-1.198), whereas 5-year survival was improved among statin users according to post hoc analysis (hazard ratio, 0.915; 95% CI, 0.846-0.990). Statin use was associated with increased risk of venous thromboembolism, hemorrhagic anemia, transfusion, and all-cause readmission within 90 days postoperatively (P<0.05).
No relationship between preoperative statin use and periprosthetic fracture following primary shoulder arthroplasty was observed. However, statin therapy did correlate with minimally increased risk of revision surgery within 5 years, which may be more reflective of improved patient survival than true implant failure. Level of evidence: III.

PMID:
42927988
Bibliographic data and abstract were imported from PubMed on 26 Oct 2026.

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