Authors
Xiaoqin Ma, Shuniu Zheng, Jinjin Kai, Xianwei Wu
Published in
Clinical, cosmetic and investigational dermatology. Volume 19. Pages 643906. Epub Oct 21, 2026.
Abstract
Psoriasis is a chronic inflammatory skin disease mediated by immune dysregulation, with a prolonged course, high recurrence rate, and limited curative options. Biologics are effective but costly, carry immunosuppressive risks, and are associated with relapse after discontinuation.
To review the potential mechanisms by which food-derived substances and edible Chinese medicinal materials improve psoriasis through immunomodulation, oxidative stress mitigation, and gut microbiota regulation, and to grade the clinical evidence descriptively.
This is a narrative review, not a systematic review. Literature was searched in PubMed, Web of Science, Cochrane Library, CNKI, and Wanfang up to June 2026. Search terms included psoriasis, diet, nutrition, microbiota, metabolism, and Traditional Chinese Medicine. Evidence grading was informed by the GRADE framework, but no formal GRADE assessment was performed.
The Mediterranean diet and weight-loss interventions have relatively higher levels of evidence. Omega-3 polyunsaturated fatty acids, bioavailable curcumin, specific probiotic strains, and some medicine-food homologous Chinese herbs show potential adjunctive benefits, but most studies are small, single-center, and lack blinding. Traditional applications of honeysuckle, wolfberry, and Coix seed are gradually being explained by modern pharmacology.
Dietary and medicine-food homologous interventions may serve as adjuncts in psoriasis management but cannot replace conventional treatment. High-quality multicenter RCTs are needed to confirm efficacy and safety.
PMID:
42928794
Bibliographic data and abstract were imported from PubMed on 26 Oct 2026.
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