Authors
Håkon Ihle-Hansen, Bente Thommessen, Sara Rise Langlo, Elin Bergh, Anne Hokstad, Stian Lydersen, Yngve Seljeseth, Ingvild Saltvedt, Torunn Askim
Published in
Journal of rehabilitation medicine. Volume 58. Pages jrm46250. Oct 26, 2026. Epub Oct 26, 2026.
Abstract
The LAST-long randomized trial tested a multidimensional, stroke coordinator-led, community-based intervention and found no overall functional benefit. Because most participants had mild stroke symptoms, whether older or frailer subgroups benefited was examined.
In this single-blinded RCT at 4 Norwegian hospitals (2019-2022), 301 participants were randomized 1:1 to monthly stroke-coordinator meetings for 18 months (structured risk assessment and individualized goals) or to standard care.
modified Rankin Scale (mRS) at 18 months.
mortality, cognition, ADLs, physical function, fatigue, and quality of life. Older age: ≥ 80 years; frailty: Frailty Index ≥ 0.2. Linear and logistic regression tested age- and frailty-intervention interactions.
mRS data were available for 268 participants (136 intervention, 132 control). Mean age 71.1 (SD 12.4); 66 (24.6%) ≥ 80; 89 (33.2%) frail. Age modified the intervention effect on mRS: among participants ≥ 80, favourable outcome was less likely with intervention vs control (23.4% vs 57.0%, p = 0.004). For secondary outcomes, the intervention improved Trail Making Test B in younger participants (-32.2 s, 95% CI -58.0 to -6.4, p = 0.015) with a significant age-intervention interaction (p = 0.019). No frailty-intervention interaction was found.
Age - but not frailty - modified response to the intervention, indicating differential effects in older participants.
gov identifier: NCT03859063.
PMID:
42929098
Bibliographic data and abstract were imported from PubMed on 26 Oct 2026.
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