Time to Treatment Failure as a Recorded Treatment-Process Measure in C-CAT. Reply to Comment on "Facility-Level Medical Oncology Specialist Availability and First-Line Time to Treatment Failure in Lung Cancer: A Nationwide C-CAT Registry Analysis. Curr. Oncol. 2026, 33, 462".

Authors

Shinya Kajiura, Hironaga Satake, Ryuji Hayashi, Takayuki Yoshino

Published in

Current oncology (Toronto, Ont.). Volume 33. Issue 10. Oct 20, 2026. Epub Oct 20, 2026.

Abstract

We thank Karabuga and Kaya for their Comment on our nationwide C-CAT registry analysis of facility-level medical oncology specialist availability and first-line time to treatment failure (TTF) in lung cancer. We agree that the heterogeneous composition of TTF events and the predominantly post-first-line timing of C-CAT registration are important to interpretation. In this Reply, we clarify that TTF should be interpreted as the duration of a recorded first-line treatment process rather than as a direct measure of progression, treatment efficacy, survival benefit, facility quality, or individual specialist contribution. We also provide group-specific information on endpoint composition and the interval from first-line treatment initiation to C-CAT registration. Because treatment-ending causes were not clinically standardized and registration timing was itself post-treatment and selection-related, we did not perform additional cause-specific or registration-interval-stratified analyses. No new patient-level analysis was performed for this Reply.

PMID:
42930199
Bibliographic data and abstract were imported from PubMed on 26 Oct 2026.

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