Authors
Federico García-Rodeja Arias, Sonia Eiras, Alberto Cordero, José Ramón Núñez-Caamaño, Sandra Feijóo-Bandin, Luis Miguel Rincón-Díaz, Javier Jiménez-Candil, Pedro Luis Sánchez, Elias Martínez-Rey-Rañal, Domingo Pascual-Figal, Begoña Cardeso, Pablo Peñafiel Verdu, Javier Garcia-Seara, María Amparo Martínez-Monzonis, José Ramón González-Juanatey, Moisés Rodríguez-Mañero
Published in
Journal of cardiovascular translational research. Volume 19. Issue 1. Oct 26, 2026. Epub Oct 26, 2026.
Abstract
Improvement of left ventricular ejection fraction (LVEF) is a relevant phenotype in heart failure with reduced ejection fraction (HFrEF), but its substrate remains unclear. In 175 HFrEF patients followed prospectively for 24 months with serial echocardiography, left atrial (LA) strain and 16 biomarkers, LVEF improvement (increase ≥ 10 points to > 40%) occurred in 80 patients (45.7%). Improvers were more often women and non-ischaemic, with smaller LV volumes, better LV longitudinal strain, shorter atrial conduction time and lower ANP, relaxin-2 and COL4A1; baseline LA volume and strain did not differ. An exploratory eight-variable model had apparent and optimism-corrected AUCs of 0.93 and 0.84. NT-proBNP and LA reservoir strain diverged progressively between groups. Improvement was associated with lower mortality (HR 0.25; 95% CI 0.08-0.75) and fewer heart failure hospitalisations (HR 0.38; 95% CI 0.18-0.78). LVEF improvement reflects progressive atrial and neurohormonal reverse remodelling rather than favourable baseline atrial mechanics.
PMID:
42931827
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 15
- Comments 0