Hamartomatous, Serrated, and Mixed Polyposis Syndromes.

Authors

Jessica E Ebrahimzadeh, Kristin Zelley, Suzanne P MacFarland, Bryson W Katona

Published in

Gastroenterology clinics of North America. Volume 55. Issue 4. Pages 565-583. Epub Sep 11, 2026.

Abstract

Gastrointestinal (GI) polyposis syndromes are diverse inherited or sporadic disorders marked by multiple GI polyps. They significantly increase the risk of GI and extraintestinal cancers. Beyond adenomatous syndromes, clinically important nonadenomatous syndromes-hamartomatous (juvenile polyposis, Peutz-Jeghers, and PTEN hamartoma tumor), serrated polyposis, and GREM1-associated mixed polyposis-require accurate diagnosis and management. Early recognition supports timely genetic testing, cascade testing in families, and appropriate surveillance and risk-reduction. This article covers their features, genetic causes, diagnosis, and cancer-risk management.

PMID:
42933934
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.

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