Updates in the Molecular Biology and Personalized Management of Lynch Syndrome.

Authors

David J Lee, Matthew B Yurgelun

Published in

Gastroenterology clinics of North America. Volume 55. Issue 4. Pages 517-542. Epub Sep 18, 2026.

Abstract

Lynch syndrome (LS) is a common hereditary cancer syndrome caused by pathogenic germline variants in one of the DNA mismatch repair genes. In the past few decades, advances in understanding the molecular basis of LS and LS-related tumorigenesis have led to the development and ongoing refinement of LS screening and diagnostic strategies. In parallel, the improved characterization and increased recognition of the wide phenotypic spectrum of LS have motivated the investigation of more tailored surveillance and prevention strategies for LS-related cancers. This article discusses progress in the understanding of LS and examines the evolving paradigms in genetic testing and surveillance.

PMID:
42933932
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.

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