Design and Validation of Evidence-Based Peripheral Chemotherapy-Induced Neuropathy Guideline Among the Children with Cancer.

Authors

Somaye Pouy, Zahra Taheri Ezbarami, Bahram Darbandi, Adel Baghersalimi, Elham Bidabadi, Mercedeh Enshaei, Mohammad Taghi Ashoobi, Nazila Javadi-Pashaki

Published in

Asian Pacific journal of cancer prevention : APJCP. Volume 27. Issue 10. Pages 3669-3677. Oct 01, 2026. Epub Oct 01, 2026.

Abstract

Chemotherapy induced peripheral neuropathy (CIPN) is a frequent and debilitating complication among children receiving chemotherapy, yet evidence based clinical guidance specific to pediatrics remains limited. This study aimed to develop and validate a clinical guideline for managing CIPN in children using the Stetler model.
This methodological study applied the five phase Stetler model (Preparation, Validation, Decision Making, Application, and Evaluation) to develop the guideline. A systematic search was performed in multiple databases, including PubMed, Cochrane Library, and Scopus, without time restrictions, and 89 studies met the inclusion criteria. Content validity was assessed using the Content Validity Ratio (CVR) and Content Validity Index (CVI). A panel of experts (physicians and nurses) evaluated the guideline using the AGREE II tool. The final guideline included three components: protocol, diagnosis/treatment, and patient education.
The guideline achieved high scores in Purpose and Scope (92%), Stakeholder Involvement (84%), and Rigor of Development (81%). Evidence supported the use of Pyridoxine and Pyridostigmine for pediatric CIPN management. The TNS-PV and ped-mTNS tools were identified as appropriate for neuropathy assessment in children aged 5-18 years. Identified implementation challenges included workforce shortages and the need for specialized training.
This evidence-based guideline provides structured recommendations for the assessment and management of pediatric CIPN. While both pharmacological and non-pharmacological strategies show promise, further research across diverse pediatric populations is recommended.

PMID:
42935058
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.

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