Dynamics of Serum Amyloid A Levels in the Blood, Brain and Liver in a Mouse Model of Focal Cerebral Ischemia.

Authors

Saki Egashira, Takafumi Nakano, Keiichi Irie, Soichiro Ushio, Akiko Manabe, Ayuko Masaki, Rie Mukai, Yoshihiko Nakamura, Masato Hosokawa, Tomomitsu Satho, Kazunori Sano, Kenichi Mishima

Published in

Acta medica Okayama. Volume 80. Issue 5. Pages 309-316.

Abstract

This study examined the dynamics of serum amyloid A (SAA) levels in the blood, brain, and liver over time using a mouse model of focal cerebral ischemia induced by occlusion of the middle cerebral artery (MCA) for 4 h followed by reperfusion. Blood SAA concentrations increased transiently after cerebral infarction, coinciding with changes in brain and liver SAA gene expression and protein levels. SAA concentrations in the brain, liver, and blood increased at similar time points after cerebral infarction, suggesting that SAA may serve as an important indicator of the associated pathological condition.

PMID:
42934928
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.

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