Antiviral Activity of Naringenin Against Equine Alphaherpesvirus Type 8 In Vitro.

Authors

Anrong You, Rongze Yang, Wei Wang, Enxin Li, Muhammad Zahoor Khan, Liangliang Li, Changfa Wang, Tongtong Wang, Juan Zhao

Published in

Veterinary sciences. Volume 13. Issue 10. Sep 27, 2026. Epub Sep 27, 2026.

Abstract

Equine alphaherpesvirus type 8 (EHV-8) is an economically significant emerging pathogen responsible for severe respiratory disease, reproductive failure, and neurological disorders in equids worldwide. The escalating prevalence of EHV-8 in large-scale donkey farming operations, particularly in China, has resulted in substantial economic losses; however, no licensed antiviral agents or prophylactic vaccines are currently available. In the present study, we evaluated the anti-EHV-8 activity of naringenin in susceptible cells and comprehensively explored the underlying molecular mechanisms. Our results demonstrated that naringenin markedly inhibited EHV-8 infection in RK-13 and NBL-6 cells in a dose-dependent manner. Moreover, naringenin blocked the replication of EHV-8 via HO-1 (heme oxygenase-1)-mediated type I interferon (IFN) response. Collectively, our findings indicate that naringenin may serve as a promising therapeutic drug for the treatment of EHV-8 infection.

PMID:
42944118
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.

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