Antiviral Action Mechanisms of a Synthetic GM-CSF Active-Center Peptide.

Authors

Aleksandr Zurochka, Mariya Dobrynina, Vladimir Zurochka, Viktor Gritsenko, Aleksandr Semenov

Published in

Viruses. Volume 18. Issue 10. Oct 10, 2026. Epub Oct 10, 2026.

Abstract

We assessed the antiviral activity of a synthetic GM-CSF active-center peptide against a number of RNA- and DNA-containing viruses, both enveloped and nonenveloped. We evaluated the antiviral activity in vitro and in vivo against parainfluenza virus type 3 (strain Vok) and adenovirus serotype 3 (strain 3/Voronezh/2174/82) in a continuous culture of human laryngeal carcinoma HEp-2 cells. Virucidal activity was evaluated against human adenovirus type 5, Coxsackievirus B3, Echovirus 30 virus, influenza virus A/Puerto Rico/8/34 (H1N1), human parainfluenza virus type 3, herpes simplex virus type 1, OC43 coronavirus, and human cytomegalovirus propagated in various permissive cell lines. The peptide exhibited a stronger prophylactic effect than the ZP2 peptide preparation and showed preferential activity against enveloped RNA viruses. We detected no cytotoxic effect of ZP2 on HEp-2 cells in vitro.

PMID:
42944044
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.

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