Authors
Jianming Ren, Peijin Song, Lan Zhang, Pengfei Zhao, Shiyu Tao, Jiancheng Jiang, Fanlin Wu, Xinsheng Lu, Peng Ji
Published in
Veterinary sciences. Volume 13. Issue 10. Sep 26, 2026. Epub Sep 26, 2026.
Abstract
Veterinary practice faces rising antimicrobial resistance, driving interest in plant-derived alternatives. Purslane (Portulaca oleracea L.), a medicinal edible herb with antimicrobial, anti-inflammatory, and immunomodulatory properties, is a promising candidate. This narrative review synthesizes 160 studies into a unified framework linking chemical composition (flavonoids, alkaloids, polysaccharides, organic acids), pharmacological activities (12 major effects), and veterinary applications. Mechanistically, polysaccharides act as immunomodulators via the TLR4/MyD88 pathway; flavonoids (quercetin, kaempferol) exert antioxidant/anti-inflammatory effects through NF-κB/MAPK inhibition and Nrf2 activation; organic acid extracts show potent anti-MRSA activity (MIC 0.5-1.0 mg/mL); and alkaloids enhance insulin secretion. In vivo, dietary purslane at 2-3% improves broiler growth performance and feed conversion, while supplementation enriches omega-3 fatty acids in eggs and meat. However, translational barriers persist, including limited pharmacokinetic data, lack of large-scale field trials, and insufficient safety and residue-depletion information for food-producing animals. We outline future priorities, including species-specific pharmacokinetic studies, field efficacy trials, and quality-control standards, positioning purslane as a mechanism-rich, antibiotic-sparing candidate for further investigation in veterinary therapeutics and functional feed additives.
PMID:
42944113
Bibliographic data and abstract were imported from PubMed on 27 Oct 2026.
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