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One factor, two safeguards: RUNX1 divides its labor across the regulatory genome.

Created on 28 Oct 2026

Authors

Kenichi Miyata, Yuta Uneme, Reo Maruyama

Published in

Cell reports. Volume 45. Issue 11. Pages 118129. Oct 27, 2026. Epub Oct 27, 2026.

Abstract

Fritz et al.1 use acute RUNX1 degradation to reveal how mammary epithelial cells maintain their state. RUNX1 links enhancer-centered control of epithelial identity with promoter-centered control of DNA-damage responsiveness.

PMID:
42945211
Bibliographic data and abstract were imported from PubMed on 28 Oct 2026.

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