Dual-Targeted Agent Improves Advanced BTC Survival.

Published in

Cancer discovery. Pages OF1. Oct 27, 2026. Epub Oct 27, 2026.

Abstract

Interim results from the phase 3 HARMONi-GI1 trial demonstrate the first-in-class PD-1×VEGF bispecific antibody ivonescimab, combined with gemcitabine and cisplatin, significantly improved overall survival compared with durvalumab plus the same chemotherapy backbone in advanced biliary tract cancer. The regimen may represent a new standard of care for first-line advanced biliary tract cancer, though questions regarding patient selection and applicability beyond Chinese populations remain.

PMID:
42945191
Bibliographic data and abstract were imported from PubMed on 28 Oct 2026.

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