Lysosomal acidification through membrane contacts with mitochondria.

Authors

Zhiqi Tian, Yujie Sun, Jiajie Diao

Published in

The Journal of cell biology. Volume 225. Issue 12. Dec 07, 2026. Epub Oct 27, 2026.

Abstract

Recent work from two independent studies has uncovered mitochondria as a previously unrecognized proton source driving lysosomal acidification. In this Viewpoint, we summarize these findings, examine the associated proteins and functional mechanisms, and discuss their relevance to disease.

PMID:
42944726
Bibliographic data and abstract were imported from PubMed on 28 Oct 2026.

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