Metabolic Dysfunction-Associated Steatotic Liver Disease in Children.

Authors

Toshifumi Yodoshi, Stavra Xanthakos

Published in

Clinics in liver disease. Volume 30. Issue 4. Pages 987-1007. Epub Sep 04, 2026.

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease among children and adolescents worldwide. Pediatric MASLD is associated with significant morbidity during childhood, including progressive liver fibrosis and incident diabetes, and significantly increases risk of premature mortality in early adulthood. In comparison to MASLD in adults, youth-onset MASLD exhibits distinct histologic patterns, lacks well-validated noninvasive tests for risk stratification and approved pharmacotherapy, and may carry higher risk of long-term liver-related mortality. Critical areas of unmet need include improving rates of recommended screening, development of pediatric-specific risk stratification tools and developing more effective prevention and treatment strategies.

PMID:
42946529
Bibliographic data and abstract were imported from PubMed on 28 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.