Outcomes of a 42-day course of molnupiravir in cats with feline infectious peritonitis: a prospective descriptive study.

Authors

Kenta Hishinuma, Akiko Inoue, Kenjiro Fukushima, Masahiko Sato

Published in

Journal of veterinary internal medicine. Volume 40. Issue 5. Sep 01, 2026.

Abstract

Antiviral therapy for cats with feline infectious peritonitis (FIP) has traditionally been administered for 84 days, although the optimal duration of molnupiravir treatment remains unknown.
To evaluate the efficacy of a 42-day course of molnupiravir, orally (PO), for naturally occurring FIP in cats.
Nineteen client-owned cats with newly diagnosed FIP.
Prospective pilot study. Cats received molnupiravir, PO, q12h for 42 days at a median dosage of 11.5 mg/kg (IQR, 10.2-12.5 mg/kg). Cats with ocular or neurological involvement were excluded. Clinical assessments were performed during treatment and for 6 months after treatment cessation.
Nineteen cats were enrolled. Two cats failed to complete treatment because of death or persistent clinical signs. Fourteen of 19 cats (74%; 95% CI, 49-91) achieved sustained remission on an intention-to-treat basis. Each non-completer failed on day 5 or 10, respectively, within a window common to 42- and 84-day protocols, and therefore do not inform the question of treatment duration; among the 17 cats reaching day 42, 14 (82%; 95% CI, 57-96) remained in remission for at least 6 months. Three cats relapsed after treatment cessation; all responded to retreatment with molnupiravir at the same dosage extended to 84 days.
This prospective study suggests that a shortened course of molnupiravir is feasible in selected cats with non-ocular, non-neurological FIP.
: (FIP) にするウイルスは 84 されてきたが、モルヌピラビルのなはらかではない。 : FIP のにするモルヌピラビル 42 のをすること。 : たに FIP とされた19。 : きパイロット。モルヌピラビルを 12 ごとに 42 した。のは 11.5  mg/kg (、 10.2-12.5  mg/kg) であった。またはをするはした。および 6 か、をった。 : 19 をした。 2 はまたはのによりをできなかった。 Intention-to-treat では 19 14 (74 %； 95% 、 49-91) がをした。の 2 はそれぞれ5および10にとなり、いずれも 42 および 84 のプロトコルにするであったため、のにはしなかった。 42 までをした 17 のうち 14 (82% ； 95% 、 57-96) はなくとも 6 かをした。 3 はにしたが、がのモルヌピラビルによる 84 のにした。 および: きパイロットのから、およびをわない FIP のでは、モルヌピラビルのがであるがされた。.

PMID:
42949438
Bibliographic data and abstract were imported from PubMed on 28 Oct 2026.

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