Authors
Aimilios Lallas, Giuseppe Argenziano
Published in
Dermatology practical & conceptual. Volume 16. Issue 2. Apr 01, 2026. Epub Apr 01, 2026.
Abstract
Nonpigmented skin tumors represent a major diagnostic challenge in dermatoscopy. In the absence of pigment, traditional pattern recognition is often unreliable, increasing the risk of misdiagnosis, particularly for melanoma and other aggressive malignancies.
To summarize key dermatoscopic features of nonpigmented skin tumors and to propose structured algorithms for the management of nonpigmented nodular and flat lesions.
A narrative review of the literature was conducted focusing on dermatoscopic criteria relevant to nonpigmented lesions, including vascular morphology, white-colored structures, and ulceration. Based on these features, pragmatic algorithms were developed to guide clinical decision-making.
While vascular structures represent the most informative dermatoscopic features in nonpigmented tumors, their specificity is limited. White-colored structures and ulceration provide additional, nonspecific clues. For nodular lesions, an exclusion-based algorithm centered on common benign entities supports conservative management only when diagnostic confidence is high; otherwise, excision is recommended. For flat lesions, a stepwise assessment of ulceration, vascular morphology, and surface keratin allows differentiation between superficial basal cell carcinoma, Bowen's disease, and lesions requiring biopsy.
Simple, conservative dermatoscopic algorithms may improve the safety and consistency of clinical decision-making in nonpigmented skin tumors, supporting early detection of malignancies while accepting a degree of benign excisions.
PMID:
42950152
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.
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