Authors
Masaki Saito, Akira Honda, Tomoki Nakajima, Kenta Takakura, Toshiki Tsukui, Kazuhiro Inomata, Eiji Takasawa, Tokue Mieda, Hirotaka Chikuda
Published in
Clinical spine surgery. Oct 26, 2026. Epub Oct 26, 2026.
Abstract
Retrospective comparative study.
To evaluate the effectiveness of an absorbable collagen matrix (DuraGen) in reducing postoperative cerebrospinal fluid (CSF) hypovolemia-related symptoms after intradural extramedullary spinal tumor resection.
CSF leakage and related symptoms are frequent complications after intradural tumor surgery. Although various adjuncts are used for watertight dural closure, their efficacy remains uncertain. The collagen matrix has shown benefits in cranial surgery, but evidence in spinal surgery is limited.
Twenty-four patients who underwent spinal tumor resection between February 2023 and April 2025 were retrospectively reviewed. Twelve underwent conventional dural repair with autologous fat, fibrin glue, and PGA mesh, and 12 underwent collagen matrix augmentation. Clinical variables, drain output, and postoperative CSF hypovolemia-related symptoms were analyzed.
The collagen matrix group had a significantly lower incidence of CSF hypovolemia-related symptoms than the conventional group (8% vs. 58%, P=0.009). Drain output on postoperative days 1 and 2 did not differ, but serosanguineous drainage was more frequent in the collagen matrix group (P=0.004).
Collagen matrix augmentation significantly reduced CSF hypovolemia-related symptoms after spinal tumor resection without increasing operative time or blood loss. It may serve as a valuable adjunct for watertight dural closure and improved patient outcomes.
PMID:
42949847
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 17
- Comments 0