STK11 Adnexal Tumor: Expanding the Spectrum of Female Genital Tumors in Peutz-Jeghers Syndrome.

Authors

Jelena Mirkovic

Published in

Surgical pathology clinics. Volume 19. Issue 4. Pages 689-701. Epub Sep 24, 2026.

Abstract

Serine-threonine kinase 11 (STK11) adnexal tumors are rare clinically aggressive neoplasms most commonly arising in the paratubal/paraovarian tissue. They are of uncertain histogenesis, characterized by STK11 genomic alterations, with a subset associated with Peutz-Jeghers syndrome. The spectrum of morphologic appearances is wide. Most commonly, cords and trabeculae in myxoid stroma are seen in addition to other components. They exhibit polyphenotypic immunoprofile with frequent expression of epithelial, mesothelial, sex cord, and smooth muscle marker desmin as well as hormone receptors, and loss of cytoplasmic STK11 expression.

PMID:
42951393
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.

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