Impact of Hypercholesterolemia on Pregnancy and Postpartum.

Authors

Andrea K Goldstein, Mary Beth Fisher, Vrinda Trivedi, Karen L Florio

Published in

Obstetrics and gynecology clinics of North America. Volume 53. Issue 4. Pages 659-672. Epub Aug 04, 2026.

Abstract

Cardiovascular disease (CVD) is a leading cause of maternal mortality and is secondary to the rising rates of prepregnancy CVD risk factors. Pregnancy represents a unique physiologic state characterized by significant alterations in lipid metabolism, which supports placental steroidogenesis and fetal growth. This article reviews the physiology of lipid metabolism in pregnancy, the pathophysiologic mechanisms linking dyslipidemia to adverse maternal and fetal outcomes, and current evidence guiding clinical management throughout gestation and the postpartum period. Emphasis is placed on risk stratification, medication safety, monitoring strategies, and long-term cardiovascular implications, with the goal of integrating lipid management into contemporary cardio-obstetric care.

PMID:
42951437
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.

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