Collagen-derived peptides enhance resistance to Pseudomonas aeruginosa infection in silkworms.

Authors

Atsushi Miyashita, Fumiaki Tabuchi, Kazuhiro Mikami, Hiroto Nakajima, Kumiko Kuwaba, Kazunori Mizuno, Yuki Taga, Masashi Kusubata, Kazuhisa Sekimizu

Published in

Drug discoveries & therapeutics. Oct 29, 2026. Epub Oct 29, 2026.

Abstract

Collagen-derived peptides are widely used as food ingredients and dietary supplements, but their effects on host defense against bacterial infection remain poorly understood. Here, we examined whether GFG-01, a granulated preparation of a fish-derived collagen hydrolysate produced using ginger protease, enhances resistance to Pseudomonas aeruginosa PAO1 infection in the silkworm (Bombyx mori). Oral administration of GFG-01 by mixing the preparation into the diet improved the post-infection outcome of larvae compared with vehicle-treated controls. Western blot analysis suggested that intrahemocoelic administration of GFG-01 induced accumulation of Cecropin B, an antimicrobial peptide, in the hemolymph. RNA-seq-based Gene Ontology enrichment analysis of samples collected after oral administration further showed tissue-dependent immune-related gene expression patterns: immune-related categories were enriched among downregulated genes in the fat body and among upregulated genes in hemocytes. These findings indicate that orally administered GFG-01 can improve the outcome of bacterial infection in silkworms and that GFG-01 is associated with modulation of host innate immune responses under the tested conditions.

PMID:
42951608
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.

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