CLAG3 mutations reduce hemoglobin S-mediated protection against malaria.

Authors

Pascal Rihet, Sandrine Marquet

Published in

Trends in parasitology. Oct 28, 2026. Epub Oct 28, 2026.

Abstract

Hemoglobin S (HbS), which confers protection against malaria, could exert selective pressure on the genome of Plasmodium falciparum. Forster et al. identified new parasite variants, including two variants shared by CLAG3 paralogs, that reduce the protective effect of HbS. These findings support the hypothesis of coevolution between humans and parasites.

PMID:
42951726
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.

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