Authors
Midori Kumagawa
Published in
[Rinsho ketsueki] The Japanese journal of clinical hematology. Volume 67. Issue 9. Pages 1093-1102.
Abstract
This review summarizes transfusion-related adverse reactions and infections based on data collected through the haemovigilance system of the Japanese Red Cross Society. Among non-hemolytic transfusion reactions, allergic reactions were the most frequently reported, while severe cases were mainly characterized by respiratory distress and hypotension. Particular emphasis is placed on transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), incorporating recent international redefinitions and their implementation in Japan. Under updated evaluation criteria, a substantial proportion of post-transfusion respiratory events are reclassified as TACO rather than TRALI, underscoring the importance of systematic assessment of pre-transfusion respiratory status, chest imaging, volume balance, and biomarkers such as BNP/NT-proBNP. In addition, hemolytic transfusion reactions, transfusion-transmitted infections, and post-transfusion iron overload are reviewed. Iron overload is highlighted as a clinically significant late complication affecting the long-term prognosis of chronically transfused patients, which may be underrecognized by haemovigilance focused on acute events. Because haemovigilance relies largely on passive reporting, clinicians should document key clinical data and report suspected events to improve classification and prevention strategies. This review provides practical insights for daily hematology practice and highlights recent safety updates, including bacterial screening of platelet components.
PMID:
42951623
Bibliographic data and abstract were imported from PubMed on 29 Oct 2026.
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