Ataxin-2 loss flips a metabolic switch for neuron health.

Authors

Fabiana Longo, Albert R La Spada

Published in

Cell reports. Volume 45. Issue 11. Pages 118128. Oct 29, 2026. Epub Oct 29, 2026.

Abstract

Gastaldo et al.¹ report that lowering ataxin-2 protects neurons from TDP-43 toxicity in amyotrophic lateral sclerosis by activating neuronal glycolysis and astrocytic cholesterol synthesis, not by reversing TDP-43-dependent molecular pathology. The downstream effectors, IDH1 and HMGCS1, thus emerge as candidate therapeutic targets.

PMID:
42955954
Bibliographic data and abstract were imported from PubMed on 30 Oct 2026.

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