Pharmacotherapy Management of Calcium Channel Blocker Toxicity in the Emergency Department.

Authors

Helen Knoche, Kyle A Weant

Published in

Advanced emergency nursing journal. Volume 48. Issue 4. Pages 213-219.

Abstract

Calcium channel blocker (CCB) overdose is a life-threatening toxicologic emergency characterized by profound cardiovascular instability. Emergency medicine personnel play a critical role in the early recognition, hemodynamic stabilization, and ongoing monitoring of these patients. This review provides a clinically focused discussion of the pathophysiology, clinical presentation, and emergency department management of CCB toxicity, with particular emphasis on intravenous fluids, atropine, calcium salts, vasopressors, hyperinsulinemic-euglycemic therapy, intravenous lipid emulsion, methylene blue, and extracorporeal membrane oxygenation. This review highlights the priorities in the monitoring and titration of therapies, underscoring the importance of a structured, multimodal approach to treatment. Early recognition and timely escalation of care are essential to improving outcomes in this high-risk population.

PMID:
42955893
Bibliographic data and abstract were imported from PubMed on 30 Oct 2026.

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